Based on the comical and moving New York Times bestseller, it tells the story of Otto Anderson, a grumpy widower whose only joy comes from criticizing and judging his exasperated neighbors. When a lively young family moves in next door, he meets his match in quick-witted and very pregnant Marisol, leading to an unexpected friendship that will turn his world upside down.

A yearly high-stakes poker game between childhood friends turns into chaos when the tech billionaire host unveils an elaborate scheme to seek revenge for the ways they've betrayed him over the years. But as his plans unfold, a group of thieves hatches plans of their breaking into the mansion thinking it is empty. The old friends quickly band together and the years of playing the game help them win their way through a night of terror.

Babes follows childhood best friends Eden and Dawn, now in different phases of adulthood. When single Eden decides to have a baby on her own after a one-night stand, their friendship faces its greatest challenge.